Curriculum Vitae

Marianne Bezaire
Email

EDUCATION

PhD in Biomedical Science Mar 2015
University of California at Irvine
Irvine, CA
Dissertation title: “Modeling physiological oscillations in a biologically constrained CA1 network from two perspectives: full-scale parallel network and rationally reduced Network Clamp”. Committee: Alan Goldin, Jeffrey Krichmar, Ivan Soltesz (Chair)

BS in Chemical (Biochemical) Engineering, magna cum laude May 2005
Minor in Neuroscience
University of Southern California
Los Angeles, CA

RESEARCH EXPERIENCE
Postdoctoral Fellow Mar 2015-present
Computational Neuroscience Lab
Department of Psychological & Brain Sciences
Boston University
Advisor: Michael Hasselmo

Graduate Research Fellow Jul 2009-Mar 2015
Department of Anatomy & Neurobiology
University of California, Irvine
Advisor: Ivan Soltesz

Research Engineer Jul 2005-Dec 2005
NSF Research Experience for Undergraduates (REU) Fellow Jun 2004-Aug 2004
Micro-Electrical- Mechanical Systems (MEMS) Lab
Department of Electrical Engineering
University of Washington, Seattle
Advisor: Karl Bohringer

Research Assistant May 2003-May 2005
Department of Neurology
School of Medicine
University of Southern California
Advisor: Joseph Miller

WORK EXPERIENCE

Senior Associate Clinical Systems Oct 2007-Jul 2009
Associate Clinical Systems Jan 2006-Oct 2007
Amgen Inc
Clinical Development

GRANTS & AWARDS

NIH NRSA Postdoctoral Fellow 2015 – present
NSF GRFP Fellow 2011 – 2014
XSEDE Startup Allocation 2011
TeraGrid Startup Allocation 2010
NSF GRFP Honorable Mention 2010
USC Chemical Engineering Outstanding Student Award 2005
USC Full Tuition Trustee Scholarship 2001 – 2005
USC Engineering Merit Research Scholarship  2001 – 2005
AIChE Student Scholarship Award 2004

PUBLICATIONS
Research Papers in Preparation and Review

  • Bezaire MJ, Hasselmo ME. Contributions of the HCN current to dorsal-ventral spike timing differences in a detailed compartmental model of a medial entorhinal cortical stellate cell. Submitted to Frontiers in Systems Neuroscience. Under Review

Research Papers

  • Bezaire MJ, Raikov I, Burk K, Vyas D, Soltesz I. Interneuronal mechanisms of hippocampal theta oscillation in a full-scale model of the rodent CA1 circuit. eLife. 2016 December 23;5. PubMed PMID: 28009257; PubMed Central PMCID: PMC5313080.
  • Armstrong C, Wang J, Yeun Lee S, Broderick J, Bezaire MJ, Lee SH, Soltesz I. Target- selectivity of parvalbumin-positive interneurons in layer II of medial entorhinal cortex in normal and epileptic animals. Hippocampus. 2016 June;26(6):779-93. PubMed PMID: 26663222; PubMed Central PMCID: PMC4866882.
  • Sokolova IV, Schneider CJ, Bezaire M, Soltesz I, Vlkolinsky R, Nelson GA. Proton radiation alters intrinsic and synaptic properties of CA1 pyramidal neurons of the mouse hippocampus. Radiation research. 2015 Jan 26;183(2):208-18. Pubmed PMID: 25621896
  • Lee SH, Marchionni I, Bezaire M, Varga C, Danielson N, Lovett-Barron M, Losonczy A, Soltesz I. Parvalbumin-positive basket cells differentiate among hippocampal pyramidal cells. Neuron. 2014 Jun 4;82(5):1129-44. PubMed PMID: 24836505; PubMed Central PMCID: PMC4076442.
  • Varga C, Oijala M, Lish J, Szabo GG, Bezaire M, Marchionni I, Golshani P, Soltesz I. Functional fission of parvalbumin interneuron classes during fast network events. Elife. 2014 Nov 6;3:e04006. PubMed Central PMCID: PMC4270094
  • Bezaire MJ, Soltesz I. 2013. Quantitative Assessment of CA1 Local Circuits: Knowledge Base for Interneuron-Pyramidal Cell Connectivity. Hippocampus: 2013:751–785.
  • Schneider CJ, Bezaire M, Soltesz I. Toward a full-scale computational model of the rat dentate gyrus. Front Neural Circuits. 2012.
  • Shastry A, Case MJ, Böhringer KF. Directing Droplets using Microstructured Surfaces. Langmuir. 2006: 6161-7
  • Case MJ, Shastry A, Böhringer KF. Towards understanding contact angle hysteresis behavior of textured surfaces. J. Undergrad. Res. Biomat. Eng. 2005:10-14

Abstracts & Posters

  • Bezaire MJ, Hasselmo ME. Mechanisms of spike timing in a detailed computer model of a medial entorhinal cortical stellate cell. Society for Neuroscience. San Diego, CA. 2016
  • Bezaire MJ, Raikov I, Burk K, Soltesz I. SimTracker: a GUI-based simulation management tool for use with parallel NEURON neural network model simulations. Ashburn, VA. 2016
  • Bezaire MJ, Soltesz I. Big Data-driven full-scale parallel computer model of the CA1 network: Insights into oscillatory interneuronal discharges. Society for Neuroscience. San Diego, CA. 2013
  • Vlkolinsky R, Sokolova IV, Schneider C, Bezaire M, Soltesz I, Nelson G. Long-term changes in neuronal excitability produced by low-dose radiation. Society for Neuroscience. San Diego, CA. 2013
  • Bezaire MJ, Soltesz I. Interneuron type-specific contributions to CA1 network activity in a data-driven computer model. Joint Symposium on Neural Computation. Pasadena, CA. 2013
  • Bezaire MJ, Soltesz I. Interneuron type-specific contributions to CA1 network activity in a data-driven computer model. Society for Neuroscience. New Orleans, LA. 2012
  • Case MJ, Soltesz I. Network mechanisms contributing to CA1 pyramidal cell subthreshold membrane potential oscillation. Joint Symposium on Neural Computation. Riverside, CA. 2012
  • Case MJ, Soltesz I. Computer modeling to understand the role of interneurons in physiological hippocampal functions. Waterville, ME. 2011
  • Case MJ, Schneider CJ, Soltesz I. Parallel Computing Enables Full-Scale Modeling of the Rat Dentate Gyrus. Joint Symposium on Neural Computation. Los Angeles, CA. 2010
  • Case MJ, Soltesz I. Spatial Processing in a Biologically Realistic Model of the Rat Dentate Gyrus. Gordon Conference on the Neurobiology of Cognition. Waterville Valley, NH. 2010
  • Shastry A, Case MJ, Böhringer KF. Engineering texture to manipulate droplets in microfluidic systems. MEMS 2005, Miami, FL. 2005: 694-7
  • Case M, Miller JD, et al. “Martian circadian rhythms: A Biosignature?” Society for Research on Biological Rhythms. Vancouver, BC. 2004
  • Case M, Miller JD, et al. “Mars, methane and circadian rhythms,” International Symposium on Optical Science and Technology, 49th annual meeting of SPIE. Denver, CO. 2004
  • Case MJ, Miller JD, et al. Hippocampal neurogenesis and the development of circadian rhythms in locomotor and ingestive behavior in MAO knockout mice. Society for Neuroscience Abstracts. Washington, DC. 2004

Book Chapters

  • Case MJ, Morgan RJ, Schneider CJ, Soltesz I. Computer Modeling of Epilepsy. In: Jasper’s Basic Mechanisms of the Epilepsies, 4th ed. New York: Oxford University Press; 2012.

Reviews

  • Case MJ, Soltesz I. Discreet charm of the GABAergic bourgeoisie: superconnected cells conduct developmental symphonies. Neuron. 2009: 780-2.
  • Case MJ. An introduction to the chemistry behind moisturizers. Illumin Magazine. 2004: http://illumin.usc.edu/article.php?articleID=118

Presentations

  • Bezaire MJ. Possible Interneuronal Contributions to Spontaneous Theta Oscillations in a Detailed Computer Model of the Isolated Rat Hippocampal CA1 Region. Cognitive Rhythms Collaborative. Boston, MA. 2017.
  • Bezaire MJ. Large-scale detailed model of a hippocampal CA1 network displays spontaneous theta. Hippo camp. Paris, France. 2017

SKILLS
MATLAB
Python
NEURON (neural simulator)
Microsoft Excel
SAS

PROFESSIONAL ASSOCIATIONS
Society for Neuroscience 2012 – present
Organization for Computational Neurosciences 2012 – present
Toastmasters International 2009 – 2012
American Association for the Advancement of Science (AAAS) 2009 – 2011

REFERENCES

References available upon request.